Figure 5

Cancellous BMC and BMD at the femoral neck measured by pQCT densitometry. Effects of alendronate (ALN), calcitriol (VitD), and combined alendronate and calcitriol treatments (ALN+VitD) on the pQCT densitometric parameters of cancellous BMC and BMD at the femoral neck in OVX rats after 12 weeks of treatment are shown. The data are presented as mean ± SD (n = 6 per group). ^### P < 0.001 as compared with corresponding values in saline-treated OVX (unpaired t-test). * P < 0.05, *** P < 0.001 as compared with corresponding values in saline-treated OVX (Tukey's multiple comparison test). OVX significantly reduced cancellous BMC and BMD. In alendronate single and the combined treatment group, a significant increment in both cancellous BMC and BMD was found. Calcitriol single treatment significantly improved cancellous BMC only.