Table 1 Characteristics of included studies
From: Intravenous versus topical tranexamic acid in spinal surgery: a systematic review and meta-analysis
Study | Operation | No.I vs. T | Mean age (years) I VS T | Study design | TXA intervention | transfusion criteria | Outcome measures |
|---|---|---|---|---|---|---|---|
Meng [17] | Posterior Lumbar surgery | 40/40 | 61 0.1 ± 5.8/62.3 ± 5.4 | RCT | I:15 mg/kg TXA IV T:15 min interval for topical administration in the wound, unlimited dose | Hb < 7 g/dl | ③④⑥⑦ |
MU [19] | PLIF | 45/39 | 54.20 ± 7.37/51.77 ± 8.13 | RCT | I:15 mg/kg in 100 mL of normal saline T:1 g TXA dissolved in 50mL of normal saline | Hb < 7 g/dl | ①②③④⑤⑥⑦ |
Ou [19] | PLF | 59/59 | 64.0 ± 5.1/64.2 ± 5.14.6 | CCT | I:15 mg/kg TXA T:1.0 g TXA in 10 mL of normal saline | Hb < 9 g/dl | ①③⑤⑥⑦ |
Wang [18] | percutaneous pedicle screw fixation | 61/62 | 45.53 ± 8.18/45.72 ± 9.96 | RCT | I:15 mg/kg TXA IV T:3 g topical TXA | NR | ①②③④⑥⑦ |
Zheng [21] | multi-segment, thoracolumbar posterior internal fusion | 24/24 | 55.3 ± 7.3/57.2 ± 5.7 | RCT | I:1%TXA Sodium Chloride Injection T:1% TXA Sodium Chloride Injection 100 ml | NR | ④⑦ |