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Fig. 2 | Journal of Orthopaedic Surgery and Research

Fig. 2

From: The role of the NOTCH1 signaling pathway in the maintenance of mesenchymal stem cell stemness and chondrocyte differentiation and its potential in the treatment of osteoarthritis

Fig. 2

The impact of NOTCH1 on the maintenance of stemness in MSCs and differentiation into chondrocytes. A. The protein bands of NOTCH1 and EZH2 in LV-NC-KD, LV-NOTCH1-KD, LV-NC-OE and LV-NOTCH1-OE groups were detected by Western blot. B. Western blot for SOX2, SOX9, KLF2, KLF4, and OCT4 in LV-NC-KD, LV-NOTCH1-KD, LV-NC-OE, and LV-NOTCH1-OE groups. C. Western blot for COL2A1, AGC-1, and COMP in LV-NC-KD, LV-NOTCH1-KD, LV-NC-OE, and LV-NOTCH1-OE groups and after addition of EZH2 inhibitor GSK126

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X