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Fig. 4 | Journal of Orthopaedic Surgery and Research

Fig. 4

From: The role of the NOTCH1 signaling pathway in the maintenance of mesenchymal stem cell stemness and chondrocyte differentiation and its potential in the treatment of osteoarthritis

Fig. 4

NOTCH1’s enhancement of chondrocyte homeostasis by stabilizing endoplasmic reticulum stress A. a. The volcano plot showed a significant increase in the expression of ATF4, C/EBPβ, RUNX2, METTL3, and EIF2α after NOTCH1 silencing. b&c. KEGG analysis showed that pathways related to inflammation response are closely associated with NOTCH1 silencing. B. Western blot experiments show the impact of changes in NOTCH1 expression on the expression of proteins such as METTLE3, p-EIF2α, ATF4, and C/EBPβ. C. Immunofluorescence experiments display changes in COL2A1 fluorescence intensity. *P<0.05, **P<0.01

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X