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Table 2 Evaluation of empty lacunae and angiogenesis

From: Exosomes secreted from human-derived adipose stem cells prevent progression of osteonecrosis of the femoral head

Variable

Control group

Exosome group

P value

Empty lacuna

   

subchondral area (%)

46.2 ± 22.6

17.4 ± 12.2

0.045

surrounding tunnel (%)

49.3 ± 22.5

12.0 ± 9.2

< 0.01

modified Mankin score

10.3 ± 0.82

7.2 ± 2.4

0.048

CD31 positive vessels

   

subchondral area

5.0 ± 4.3

31.8 ± 44.3

0.57

surrounding tunnel

10.5 ± 8.3

18.7 ± 15.6

0.52

  1. Histological assessment at 12 weeks. The p-values shown correspond to comparisons with the control group. Quantitative analysis of empty lacunae (%) in the subchondral bone and the area surrounding the tunnel (n = 6) indicated significantly decreased empty lacunae in the exosome group at the surrounding tunnel. The Modified Mankin score was significantly higher in the exosome group. Analysis of the number of vessels with CD31-positive staining showed no significant difference between the groups
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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X