Table 2 Methodology of in-vitro testing
From: Evaluation and testing of polymethylmetacrylic (PMMA) bone cements with admixed Amphotericin B
Cement formulation | Test / Limit | ||||
|---|---|---|---|---|---|
Compressive Strength [MPa] <70 Mpa | Bending Modulus [MPa] < 1800 Mpa | Bending Strength [MPa] < 50 Mpa | Impact/Strength [kJ/m2] < 2.5 kJ/m2 | Elution in µg per sample | |
Palacos R plain | ☑ | ☑ | ☑ | ☑ | |
Palacos R + 0.5 g pure Amphothericin B | ☑ | ||||
Palacos R + 0.8 g pure Amphothericin B | ☑ | ☑ | ☑ | ☑ | |
Palacos R + 30 mg active ingredient/0,8 g AmBisome® | ☑ | ☑ | ☑ | ☑ | |
Palacos R + G plain | ☑ | ☑ | ☑ | ☑ | |
Palacos R + G + 0.8 g pure Amphothericin B | ☑ | ☑ | ☑ | ☑ | |
Palacos R + G + 30 mg active ingredient/0,8 g AmBisome® | ☑ | ☑ | ☑ | ☑ | |
Palacos R + G + 2.66 g pure Amphothericin B | ☑ | ☑ | ☑ | ☑ | |
Palacos R + G + 100 mg active ingredient 2,66 g AmBisome® | ☑ | ☑ | ☑ | ☑ | |
Copal G + C plain | ☑ | ☑ | ☑ | ☑ | |
Copal G + C + 50 mg active ingredient/1,33 g AmBisome® | ☑ | ☑ | ☑ | ☑ | |