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Fig. 1 | Journal of Orthopaedic Surgery and Research

Fig. 1

From: RANKL-mediated osteoclastic subchondral bone loss at a very early stage precedes subsequent cartilage degeneration and uncoupled bone remodeling in a mouse knee osteoarthritis model

Fig. 1

Changes in bone parameters in the four groups. A Representative axial and sagittal micro-CT images at 0, 1, 4, and 12 weeks after surgery in the THM + DMM and WT + DMM groups. Upper row: axial images. Lower row: sagittal images. B Changes in BV/TV in the four groups. C Changes in Tb.Th. D Changes in Tb.Sp. E Changes in BMD. Significant differences: BV/TV, Tb.Th, and TB.Sp for WT + DMM vs. WT + sham at > 4 weeks (p = 0.0013 at 4 weeks); BMD for WT + DMM vs. WT + sham at > 8 weeks; BV/TV for WT + DMM at time-0 vs. > 4 weeks (p = 0.0024 at 4 weeks); BMD for WT + DMM at time-0 vs. > 8 weeks; BV/TV, Tb.Th, and TB.Sp for THM + DMM vs. THM + sham at > 1 week (p < 0.001 at 1 week); BMD for THM + DMM at time-0 vs. > 2 weeks (p = 0.0080 at 2 weeks); BMD for THM + DMM vs. THM + sham at > 2 weeks (p = 0.049 at 2 weeks)

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X