Fig. 5

NAC mitigates cisplatin-induced apoptosis through LOX-1 and MAPK mechanisms in chondrocytes. A Apoptosis markers—cytosolic cytochrome c, Bax, and Bcl-2—were evaluated through Western blotting. B–D Calculated protein expression ratios (mean + SD). E Caspase-3 and F TUNEL expression in the cisplatin-stimulated chondrocytes treated with the ERK inhibitor, p38 inhibitor SB203580, NF-κb inhibitor, NAC and LOX-1 siRNA. *p < 0.05 comparison with control; and #p < 0.05: comparison with cisplatin group, respectively