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Fig. 6 | Journal of Orthopaedic Surgery and Research

Fig. 6

From: LINC00968 accelerates osteogenic differentiation of bone marrow mesenchymal stem cells via the miR-17-5p/STAT3 axis

Fig. 6

STAT3 is targeted by miR-17-5p. A. The target of miR-17-5p was predicted by the starbases. B. Venn diagram displayed the overlapping targets of miR-17-5p and OP-related targets. C. The overlapping targets were examined by the PPI network, and the top 5 hub genes were identified. D. The putative binding site of STAT3 for miR-17-5p. E-F. The dual luciferase reporter assay and RIP assay were conducted to examine the relationship between STAT3 and miR-17-5p. G-H. The levels of STAT3 in the bone tissue and serum of patients with OP were examined. I-J. The Spearman coefficient correlation examined the relationship between serum miR-17-5p with serum STAT3 or serum LINC00968. K. Changes in STAT3 expression in hBMSCs with increasing OM induction time. L. Effect of OM-inducted and transfected si-LINC00968 and miR-17-5p inhibitor on STAT3 levels in hBMSCs. ** P < 0.01, *** P < 0.001, **** P < 0.000

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X