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Table 1 Baseline characteristics of randomized controlled trials included in the systematic review

From: Comparative efficacy of different doses of platelet-rich plasma injection in the treatment of knee osteoarthritis: a systematic review and network meta-analysis

Study

Country

Interventions (Number of Subjects; Mean Age [y])

Grade of Osteoarthritis

Injection Interval

Outcome Reported (Follow-up)

Görmeli, 2017

Turkey

PRP1 (n = 44; 53.8)

PRP3 (n = 39; 53.7)

Kellgren–Lawrence grades 0 to IV

1 week

VAS (6 months)

Kavadar, 2015

Turkey

PRP1 (n = 34; 53.6)

PRP2 (n = 34; 54.9)

PRP3 (n = 34; 55.2)

Kellgren–Lawrence grade III

2 weeks

VAS and WOMAC (1, 3, and 6 months)

Lewis, 2022

Australia

PRP1 (n = 47; 55.1)

PRP3 (n = 27; 59.4)

Kellgren–Lawrence grades 0 to II

1 week

VAS (1, 3, and 6 months)

Patel, 2013

India

PRP1 (n = 27; 53.1)

PRP2 (n = 25; 51.6)

Ahlback grades I to III

3 weeks

VAS (6 months) and WOMAC (1, 3, and 6 months)

Simental-Mendía, 2019

Mexico

PRP1 (n = 18; 54.6)

PRP3 (n = 17; 60.1)

Kellgren–Lawrence grades I and II

2 weeks

VAS and WOMAC (1, 3, and 6 months)

Subramanyam, 2021

India

PRP1 (n = 30; 48.4)

PRP2 (n = 30; 46.7)

PRP3 (n = 30; 47.6)

Kellgren–Lawrence grades I and II

2 weeks

VAS (1, 3, and 6 months)

Tavassoli, 2019

Iran

PRP1 (n = 27; 63.2)

PRP2 (n = 27; 66.0)

Ahlback grades I and II

3 weeks

VAS and WOMAC (3 and 6 months)

Uslu Güvendi, 2018

Turkey

PRP1 (n = 19; 62.3)

PRP3 (n = 14; 60.4)

Kellgren–Lawrence grade III

1 week

VAS and WOMAC (3 and 6 months)

Yurtbay, 2022

Turkey

PRP1 (n = 62; 53.3)

PRP3 (n = 63; 57.4)

Kellgren–Lawrence grades I to III

4 weeks

VAS (1, 3, and 6 months)

Zhuang, 2024

China

PRP1 (n = 36; 58.8)

PRP3 (n = 35; 59.9)

Kellgren–Lawrence grades I to III

1 week

VAS and WOMAC (1, 3, and 6 months)

  1. Abbreviations: PRP, Platelet-rich plasma; PRP1, Single PRP injection; PRP2, Two PRP injections; PRP3, Three PRP injections; VAS, Visual Analogue Scale; WOMAC, Western Ontario and McMaster Universities Osteoarthritis Index