Effects of semaglutide in patients with chronic ankle instability: evidence from a prospective cohort

Table 3 Direct effect of semaglutide and indirect effect mediated by weight loss

Exposure: Semaglutide	Mediator: Change in BMI Endpoint: Change in FAAM sports subscale*
Controlled direct effect	12.2 (9.1, 15.4)
Indirect effect	4.0 (2.9, 5.3)
Total effect	16.3 (13.2, 19.3)
Proportion mediated	31.2% (22.2%, 41.2%)
Exposure: Semaglutide	Mediator: Change in BMI Endpoint: Change in FAAM ADL subscale*
Controlled direct effect	6.4 (4.3, 8.4)
Indirect effect	2.9 (2.1, 3.8)
Total effect	9.2 (7.2, 11.3)
Proportion mediated	34.1% (24.4%, 44.8%)

FAAM, Foot and Ankle Ability Measure; ADL, activities of daily living. * The model was adjusted for age, sex, baseline BMI, T2DM and baseline corresponding scores

ISSN: 1749-799X