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Table 3 Main outcomes of the studies

From: Virtual and augmented reality for anxiety reduction in orthopedic patients and providers: a systematic review

Author

Groups

Overall Results

VR

Non-VR

[44]

Group1: 6 patients using Oculus Rift

Group2: 38 patients using Oculus Quest

N/R

-VR was efficient in procedural pain and anxiety

- HCPs were found it effective in managing patient’s anxiety, and were satisfied from the results

-VR was easily integrated in clinical workflow

[15]

VR group: using VR headset + regional anesthesia

Regional anesthesia

-Significant reduction of anxiety only in VR group

-Lower level of intraoperative anxiety in VR group

-Increased postoperative satisfaction in VR group

[37]

Patients in the VR group watched a 5-min VR video through VR goggles

Patients in the standard preoperative experience were provided with routine audiovisual descriptions of the preoperative experience

-Significant lower level of postoperative anxiety in VR group

-Significant correlation between lower anxiety and use of VR

-Lower stress in VR group

-Higher preparedness in VR group

-Higher satisfaction in VR group

[20]

VR or AR

Group1: 15 patients using Audiovisual (AV) monitor-flat screen

Group2: 15 patients no VR and AV

-Significant reduction in anxiety from baseline to preoperative in VR group

-Lower preprocedural anxiety in intervention groups but no significant changes between groups

[18]

standard care: 2 mL hyperbaric bupivacaine 0.5% added with 0.2 mL of sufentanil 5 μg/mL + VR glasses and headphone

Standard care: 2 mL hyperbaric bupivacaine 0.5% added with 0.2 mL of sufentanil 5 μg/mL

-Similar postoperative anxiety and pain in both groups

- Significant lower dose of midazolam in VR group

[19]

four-session immersive virtual reality curriculum with a minimum of 2 and a maximum of 10 days between sessions

N/A

- Anxiety was reduced significantly

-Significant lower operative time with using VR

-Lower assistive prompts and anxiety with using VR

-Higher confidence (significant) and real-world skills with using VR (84% vs. 11%)

[20]

cast:1.VR gaming simulation2.VR goggles with noninteractive pin:VR gaming simulation2.VR goggles with noninteractive

Oculus, Meta Platforms Inc

-No differences in preprocedural to postprocedural VAS pain

-No differences in preprocedural to postprocedural VAS anxiety

[21]

Continuous passive motion device (CPM) + VR headset

CPM

- Not significant lower preoperative and postoperative anxiety in VR group

-Significant reduction in pain and anxiety in both groups (no difference between groups)

[22]

This group conducted a VR simulation of inserting the same TFN-ADVANCEDâ„¢ Proximal Femoral Nailing System (TNFA system) which that comprised a halo headband with incorporated visual lenses and two handheld controllers

The traditional group training consisted of operative technique (Optech) notes for insertion of the TFNA

-Lower anxiety levels (33% vs. 55%) and higher confidence in VR group (84% vs. 61%)

[8]

access to a fully immersive interactive VR video via their smart phone using a unique app (VIRTI)

An hour-long simulation session on the management of a multiply injured trauma patient, in line with ATLS principles

-Lower level of anxiety of trauma calls in VR group (significant)

- VR group was faster

[23]

They wore VR headset and headphones

not VR

-Significant lower anxiety and pain scores during injection, during the procedure, and at the end of the procedure in VR group

-Patients with preexisting anxiety had only lower intraprocedural anxiety

[24]

SOC + VR headset and controller

Standard of care (SOC)

-Mean preoperative anxiety was lower in VR (no statistical report)

-Significant lower intra- and post-procedural anxiety in VR group

[26]

Four-week conventional rehabilitation + 8 VR therapy sessions during their rehabilitation

Four-week conventional rehabilitation (standard care)

-Reduction in HADS score in VR group was significantly higher than control

- Lower post-treatment anxiety in VR group (significant)

-Reduction in pain score in both groups

[25]

VR headset + axillary block

No specific intervention

-No difference in intraoperative anxiety

-VR group experienced higher reduction of anxiety (not statistically different from control)

[29]

Using VR headset

No specific intervention

-Significant lower anxiety and fear scores during the procedures in VR group

-No differences between fear and anxiety scores before and after the procedures in both groups

-Higher satisfaction scores in VR group

[27]

1) VR headset coupled with a control tablet pre-operatively

2) VR headset coupled with a control tablet in fracture clinic

Standard care facilitated by a play specialist, involving conventional distraction techniques such as games and toys

-Lower level of anxiety in parents and patients in VR intervention (significant)

-Similar level of pain in both groups

Improvements the hospital experience in both groups

[30]

They received both the standard surgical instruction packet and the AR experience

They received only the standard surgical instructions packet provided to all patients

-significant reduction of level of screening to preoperative anxiety in AR group compared to control

-No significant difference in screening to postoperative anxiety (controls experienced higher reduction)

-Reduction in anxiety score in postoperative survey in both groups

-No difference between pain scores in both groups

[28]

Using the VR headset (+ sedative drugs if required)

Without the headset and with the standard protocol (+ sedative drugs if required)

-Higher postoperative anxiety level in VR group (not significant)

-Lower sedation and intraoperative adverse event in group 1

-Higher in comfort score in VR group (significant)

-No difference in patient satisfaction in both groups

[32]

spinal anesthesia + VR headset

Group1: standard care was applied to the control group

Group2: The CD and a CD player were given to the patient (PMR group)

-Higher intragroup STAI-S scores in the PMR and VR groups (significant)

-Higher satisfaction scores in the PMR and VR groups (significant)

[31]

They wore VR Hypnosis Mask during procedure

No specific intervention

-Lower postoperative and discharge anxiety scores in VR group (significant)

-Significant Reduction in using analgesics like ketamine in VR group

[35]

An AR app was offered; included 10 kinds of respiration training, 34 kinds of resistance muscle training, and walking training

A pre-recorded video was provided to patients who chose conventional perioperative rehabilitation

-Higher level of anxiety reduction in VR group (not significant)

-patients using the AR app had better subjective and objective outcomes

[33]

using headset

No specific intervention

-Significant reduction in anxiety

-A total of 66% (21) showed a reduction in anxiety scores, 28% (9) had no change in score

-No adverse events were recorded

[36]

Patients in the VR group watched a 3D model of their own MRI through a VR headset

Patients in the non-VR (NR) group received standard preoperative information about their MRI

-Lower preoperative anxiety level in VR group: in two subscales were significant: surgery-related and combined anxiety; in two was not significant: anesthesia- and information-related anxiety

-Higher pre- and postoperative satisfaction in VR group (significant)

-preoperative stress did not differ, but postoperative stress was significantly lower in VR group

-No difference in preoperative preparedness

[34]

spinal anesthesia + Immersive experience was provided through a mobile phone-based HMD showing videos and headphone playing audios

Spinal anesthesia (0.02 mg·kg − 1 of intravenous midazolam)

-Lower postoperative anxiety level in VR group (Significant)

-Higher satisfaction in VR group (significant)

-No difference in anxiety scores from the preoperative to postoperative in both groups