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Fig. 3 | Journal of Orthopaedic Surgery and Research

Fig. 3

From: Icariin promotes osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) by activating PI3K-AKT-UTX/EZH2 signaling in steroid-induced femoral head osteonecrosis

Fig. 3

Icariin activates the PI3K-AKT-UTX/EZH2 signaling in DEX-stimulated BMSCs. (A) Western blotting was performed to quantify protein levels of factors involved in the PI3K-AKT-UTX/EZH2 pathway. (B) The ratios of phosphorylated (p) PI3K/PI3K and p-AKT/AKT were measured in control, DEX, DEX + icariin-L/M/H, and DEX + PTH groups. (C) Quantification of UTX, EZH2, phosphorylated EZH2, and H3K27me3 levels in six groups. ***p < 0.001 versus control group, ###p < 0.001 versus DEX group

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X