Fig. 2

Identification of genes associated with OS prognosis and establishment of prognostic risk models. A Univariate Cox regression analyses of gene expression and overall survival of OS. B LASSO regression coefficient path plot. C Cross-validation curve for LASSO regression. D–E Risk score (D) and overall survival (E) status in the training cohort. F Heatmap of the distribution of the eight genes showing the expression differences of PMRGs in the high- and low-risk groups. G Difference in the survival outcomes between the two groups. H ROC curve showing the prediction accuracy of the risk signature. OS, osteosarcoma; PMRGs, polyamine metabolism-related genes; LASSO, least absolute shrinkage and selection operator; ROC, receiver operating characteristic