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Fig. 3 | Journal of Orthopaedic Surgery and Research

Fig. 3

From: Parthenolide ameliorates glucocorticoid-induced inhibition of osteogenic differentiation and osteoporosis by activating ERK signaling pathway

Fig. 3

PTL accelerates osteogenic differentiation of MC3T3-E1 cells by activating ERK signaling. (A-B) Western blotting assessed the levels of ERK phosphorylation in MC3T3-E1 cells treated with DEX, PTL, and U0126. (C-D) ALP staining and (E-F) Alizarin Red staining in MC3T3-E1 cells treated with DEX, PTL, and U0126. N = 3. **p < 0.01 vs. OM group; #p < 0.05, ##p < 0.01 vs. DEX group; &&p < 0.01 vs. PTL group. PTL, parthenolide; DEX, dexamethasone; ALP, alkaline phosphatase; OM, osteogenic medium; ERK, extracellular signal-regulated kinase

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X