The efficacy of liposomal bupivacaine in parasacral ischial plane block for pain management after total knee arthroplasty: a randomized controlled trial

Table 2 Summary of Results from Other Efficacy Assessments

Variables	Group A (n = 22)	Group B (n = 23)	p value
NRS-AUC
NRS-AUC R _0-72 h	132.3	97.3	0.001^*
NRS-AUC R _0-24 h	47.5 (14.1)	26.6 (11.1)	0.001^*
NRS-AUC R _0-48 h	115.6 (18.7)	82.7 (15.8)	0.001^*
NRS-AUC R _24-48 h	68.2 (12.8)	56.1 (11.3)	0.002^*
NRS-AUC R _48-72 h	16.6 (8.1)	14.6(9.7)	0.450
NRS-AUC A _0-24 h	148.5 (114.0–162.0 [45.0–171.0]) ^†	132.0 (99.0–159.0 [33.0–192.0])	0.413
NRS-AUC A _0-48 h	339.0 (298.5–366.8 [252.0–399.0])	333 (306–360 [180.0–339.0])^†	0.557
NRS-AUC A _0-72 h	484.0 (54.2)	474.9 (73.6)	0.642
NRS-AUC A _24-48 h	201.0 (174.0–217.5 [150.0–234.0])	198 (189.0–213.0 [147.0–231.0])^†	0.891
NRS-AUC A _48-72 h	150.9 (32.1)	151.0 (26.6)	0.992
OME, mg
Total	108.4 (52.6–154.9 [22.1–224.4])	107.8 (81.2–122.9 [0.0–156.2])^†	0.563
POD 1	43.1 (24.1–60.9 [0.0–190.1])^†	27.2 (5.4–41.0 [0.0–54.6])	0.009^*
POD 2	52.3 (26.7)	40.7 (20.3)	0.107
POD 3	6.0(0.0–11.0[0.0–29.6])^†	5.1 (0.0–9.1[0.0–21.8]) ^†	0.628
Primary pain site			0.022^*
Anterior knee	15 (68.2%)	22 (95.7%)
Posterior knee	7 (31.8%)	1 (4.3%)
Time to first rescue analgesic, h	12.5 (11.0–16.0 [8.0–25.0])^†	16.0 (14.0–19.3 [11.0–27.0])^‡	0.004^*
Satisfaction with analgesia	5 (4.8–5[3, 5]) ^†	5 (5–5[4, 5])^†	0.348
Onset time, min
Sensory block	60	35	< 0.001^*
Motor block	85	50	< 0.001^*
Regression time, h
Sensory block	36	48	0.280

NRS: numerical rating scale score; AUC: the cumulative area under the curve; NRS-AUC: the AUC of NRS; NRS-AUC R/A _time: the AUC of NRS at rest or activity during times; OME, oral morphine equivalents
Values are number (proportion), mean (SD) or median (IQR [range])
*Denotes statistical significance (p < 0.05); † data is skewed; ‡ one patient did not receive rescue analgesia, n = 22

ISSN: 1749-799X