Fig. 3

Effect of miR-654-3p levels on fracture healing. (A) Effect of different transfection on miR-654-3p levels; (B) Inhibition of miR-654-3p levels decreases the levels of markers of osteoblast activity and differentiation, and increasing miR-654-3p expression increases these markers levels; (C) High expression of miR-654-3p enhances cell proliferation; D and E. Low expression of miR-654-3p increases apoptosis, promotes levels of pro-apoptotic factors and decreases expression of anti-apoptotic factors (*** P < 0.001 vs. OI)