Fig. 1

Obacunone (OB) ameliorates cartilage lesions in rat with ACLT-induced OA. A Safranin O-fast green (Top) and HE staining (Bottom) assays were performed to detect the structural integrity of the articular cartilage in ACLT rats administrated with 2.5, 5, or 10 mg/kg OB. Scale bar = 50 µm. B OARSI score was used to evaluate the articular cartilage based on the results of Safranin O-fast green staining. C The level of COMP in rat serum was measured for the detection of articular cartilage. n = 6. Data were analyzed by one-way ANOVA followed by Tukey's post hoc test. *P<0.05 and ***P<0.001