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Fig. 7 | Journal of Orthopaedic Surgery and Research

Fig. 7

From: LncRNA HCG18 regulates the progression of spinal tuberculosis by modulating the hsa-miR-146a-5p/TGF-β1/SMADs pathway

Fig. 7

Knocking down HCG18 in vivo can significantly alleviate nucleus pulposus destruction in rats with spinal tuberculosis. (A) Knocking down HCG18 in vivo significant decresed the expression of HCG18 and SMAD4, but increase the expression of hsa-miR-146a-5p expression in the nucleus pulposus tissue of ST rats (n = 6, *** p < 0.001). (B) Knocking down HCG18 in vivo can significantly decrease the protein expression levels of phospho-SMAD2, phospho-SMAD3, SMAD4, and TGF-β1, and increase expression levels of SMAD7 in nucleus pulposus samples from ST rats (n = 6). (C) The HE and Safranin O staining showed that nucleus pulposus destruction is significant in rats with spinal tuberculosis, but could be improved by injection of si-HCG18 (n = 6)

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X