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Fig. 2 | Journal of Orthopaedic Surgery and Research

Fig. 2

From: Omeprazole exacerbates intervertebral disc degeneration through Caspase-3 mediated apoptosis of nucleus pulposus cells: a Mendelian randomization, network toxicology, and in vitro experimental study

Fig. 2

Integrative network analysis of omeprazole-IVDD interactions: A STRING-based protein interaction network of omeprazole targets; B Venn diagram illustrating target gene overlap between omeprazole and IVDD; C Drug-target-disease interaction network mapping omeprazole-IVDD pathological associations; D Top 10 enriched Gene Ontology terms (BP: biological processes; CC: cellular components; MF: molecular functions) for shared targets; E KEGG pathway enrichment analysis of intersecting genes; F Protein–protein interaction (PPI) network highlighting hub genes in omeprazole-induced IVDD

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X