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Table 2 Perioperative blood loss, postoperative laboratory test, transfusion and complications in two cohorts

From: Perioperative blood loss of sequential administration of hemocoagulase Agkistrodon and Tranexamic acid for primary total knee arthroplasty: a randomized controlled trial

Projects

HCA and TXA (n = 29)

TXA only (n = 30)

MD (95%CI)

P value

Cohen’D

Duration of surgery (min) a

77.2 ± 12.5

76.6 ± 11.2

0.6(-5.6-16.7)

0.907

0.04

IBL (mL) a

148.3 ± 60.5

133.3 ± 56.2

15.0(-15.4-45.3)

0.328

0.26

TBL (mL) a

1025.3 ± 305.3

892.4 ± 306.4

132.9(-26.6-294.4)

0.079

0.44

HBL (mL) a

877.0 ± 294.6

759.0 ± 282.4

118.0(-32.4-268.4)

0.122

0.41

Hemoglobin (g/L) a

     

 Postoperative 4 h

117.7 ± 10.7

123.4 ± 13.8

-5.7(-12.2-0.7)

0.081

-0.47

 Postoperative day 1

106.7 ± 11.0

111.3 ± 12.6

-4.6(-10.8-1.5)

0.134

-0.4

 Postoperative day 2

100.9 ± 11.0

107.6 ± 12.5

-7.6[-12.9-(-0.6)]

0.032

-0.57

 Postoperative day 14

125.0 ± 10.8

126.3 ± 12.8

-1.3(-8.0-5.4)

0.7

-0.11

Albumin (g/L) a

     

 Postoperative day 1

39.0 ± 1.9

39.1 ± 1.8

-0.1(-1.1-0.8)

0.772

-0.08

 Postoperative day 2

37.3 ± 2.0

37.7 ± 1.8

-0.4(-1.3-0.6)

0.46

-0.19

 Postoperative day 14

45.6 ± 1.9

45.7 ± 1.7

-0.1[-0.4-(-0.1)]

0.805

-0.07

 Transfusion (U) a

0

0

NA

NA

NA

Postoperative CRP (mg/L) a

     

 Postoperative day 1

48.8 ± 33.5

45.1 ± 33.8

3.7(-13.8-21.3)

0.655

0.11

 Postoperative day 2

104.9 ± 52.0

94.2 ± 60.4

10.7(-18.7-40.2)

0.282

0.19

 Postoperative day 14

3.8 ± 1.9

3.4 ± 2.6

0.4(-0.7-1.7)

0.083

0.21

Postoperative IL-6 (pg/ml) a

     

 Postoperative day 1

99.8 ± 105.4

99.6 ± 87.3

0.2(-50.2-50.6)

0.555

0.01

 Postoperative day 2

65.6 ± 36.3

57.9 ± 34.0

7.7(-10.6-26.1)

0.405

0.22

 Postoperative day 14

3.9 ± 3.0

3.2 ± 1.9

0.7(-0.6-2.0)

0.307

0.29

Pain VAS score a

     

 Postoperative day 1

4.7 ± 1.4

4.5 ± 1.3

0.2(-0.5-0.8)

0.741

0.12

 Postoperative day 2

4.0 ± 0.9

4.0 ± 1.0

-0.0(-0.5-0.5)

0.881

-0.04

 Postoperative day 14

1.2 ± 1.2

1.2 ± 1.1

0.0(-0.2-0.7)

0.996

0.45

Complications b

     

 DVT

0

0

NA

NA

/

 CMVT

1

3

0.5(0.1–1.5) c

0.612

/

 PE

0

0

NA

NA

/

 incision infection

0

0

NA

NA

/

 Incision bleeding

2

1

1.3(0.4–2.3) c

0.612

/

 Peri-incision bruise

1

1

1.0(0.2–2.1) c

> 0.999

/

 Allergic reaction

0

0

NA

NA

/

 Abnormal function of liver

0

0

NA

NA

/

 Abnormal function of kidney

0

0

NA

NA

/

  1. a The values are given as mean ± standard deviation; b The values are given as numbers;c The values are given as RR (95%CI); MD: mean difference; CI: confidence interval; RR: relative risk
  2. TBL, total blood loss; IBL, intraoperative blood loss; HBL, hidden blood loss; DVT, deep vein thrombosis; PE, pulmonary embolism; CRP, C-reactive protein; IL-6, interleukin 6; VAS, visual analogue scale; CMVT, Calf muscular venous thrombosis