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Table 3 Postoperative platelet counts and coagulation laboratory values in two cohorts

From: Perioperative blood loss of sequential administration of hemocoagulase Agkistrodon and Tranexamic acid for primary total knee arthroplasty: a randomized controlled trial

Projects

HCA and TXA (n = 29)

TXA only (n = 30)

MD(95%CI)

P value

Cohen’s D

Postoperative platelet counts (10^9/L)

     

 Postoperative day 1

178.1 ± 50.0

170.1 ± 55.5

8.0(-20.0-36.2)

0.566

0.17

 Postoperative day 2

171.2 ± 45.1

167.8 ± 48.5

3.4(-21.0-27.8)

0.781

0.11

 Postoperative day 14

267.1 ± 78.7

253.8 ± 78.5

13.3(-28.1-54.6)

0.523

0.17

Postoperative thrombin time (sec)

     

 Postoperative day 1

16.0 ± 1.0

16.1 ± 0.7

-0.1(-0.6-0.3)

0.925

0.87

 Postoperative day 2

15.2 ± 0.5

15.3 ± 0.6

-0.1(-0.4-0.2)

0.681

0.55

 Postoperative day 14

16.9 ± 0.9

16.8 ± 0.6

0.1(-0.3-0.4)

0.494

0.76

Postoperative APTT (sec)

     

 Postoperative day 1

26.3 ± 2.2

26.3 ± 2.3

-0.0(-1.2-1.2)

0.982

-0.01

 Postoperative day 2

27.7 ± 3.2

28.7 ± 2.8

-1.0(-2.6-0.5)

0.186

-0.35

 Postoperative day 14

25.3 ± 1.8

26.2 ± 2.1

-0.9(-1.9-0.2)

0.098

-0.44

Postoperative INR

     

 Postoperative day 1

1.03 ± 0.09

1.03 ± 0.09

0.00(-0.04-0.02)

0.772

0.02

 Postoperative day 2

1.04 ± 0.10

10.6 ± 0.08

-0.02(-0.06-0.02)

0.542

-0.16

 Postoperative day 14

1.02 ± 0.06

1.03 ± 0.05

-0.01(-0.04-0.02)

0.636

-0.12

Postoperative PT (sec)

     

 Postoperative day 1

11.5 ± 1.0

11.5 ± 1.1

-0.0(-90.6-0.5)

0.687

-0.31

 Postoperative day 2

11.5 ± 1.0

11.6 ± 0.9

-0.1(-0.6-0.4)

0.623

-0.24

 Postoperative day 14

10.9 ± 0.7

11.1 ± 0.6

-0.2(-0.5-0.2)

0.319

-0.64

Postoperative fibrinogen(g/L)

     

 Postoperative day 1

3.2 ± 0.6

3.5 ± 0.6

-0.3(-0.6-0.0)

0.044

-0.61

 Postoperative day 2

4.8 ± 1.0

5.3 ± 1.2

-0.5(-1.1-0.0)

0.066

-0.49

 Postoperative day 14

3.2 ± 0.6

3.5 ± 0.5

-0.3(-0.6-0.0)

0.074

-0.48

Postoperative FDP(mg/L)

     

 Postoperative day 1

12.5 ± 6.1

6.0 ± 3.4

6.5(4.0-9.1)

< 0.001

1.33

 Postoperative day 2

6.0 ± 2.2

5.2 ± 1.8

0.8(-0.3-1.8)

0.269

0.37

 Postoperative day 14

9.1 ± 6.1

9.4 ± 5.8

-0.3(-3.4-2.8)

0.732

-0.05

Postoperative D-dimers (mg/L)

     

 Postoperative day 1

7.1 ± 5.2

2.5 ± 2.7

4.6(2.5–6.9)

< 0.001

1.1

 Postoperative day 2

2.2 ± 0.9

1.7 ± 0.6

0.5(0.1–0.8)

0.04

0.55

 Postoperative day 14

5.5 ± 2.6

5.6 ± 2.8

-0.1(-1.4-1.2)

0.904

-0.03

  1. The values are given as mean ± standard deviation; MD: mean difference; CI: confidence interval
  2. APTT, activated partial thromboplastin time; INR, international normalized ratio; PT, prothrombin time; FDP, fibrin degradation products;
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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X