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Table 4 Stratified analysis of factors for TBL in different subgroups

From: Perioperative blood loss of sequential administration of hemocoagulase Agkistrodon and Tranexamic acid for primary total knee arthroplasty: a randomized controlled trial

Stratification factors

MD ± SD of TBL (n)

P value

Cohen’s D

HCA and TXA (n=29)

TXA only (n=30)

Gender

    

 Male

1130.7 ± 390.0 (n=6)

1134.5 ± 437.5 (n=6)

0.988

-0.09

 female

997.8 ± 283.3 (n=23)

831.8 ± 240.1 (n=24)

0.035

0.63

age (years)

    

 ≤65

1037.0 ± 264.5 (n=13

926.8 ± 159.5 (n=12)

0.225

0.5

 >65

1015.8 ± 343.3 (n=16)

869.4 ± 377.2 (n=18)

0.248

0.41

BMI (Kg/m2)

    

 ≤25

881.3 ± 224.3 (n=8)

882.7 ± 257.4 (n=8)

0.99

-0.01

 25-27

942.6 ± 287.4 (n=11)

861.1 ± 199.2 (n=9)

0.481

0.33

 >27

1231.4 ± 291.7 (n=10)

920.0 ± 400.2 (n=13)

0.05

0.87

Hemoglobin baseline (g/L)

    

 ≤135

998.2 ± 260.7 (n=16)

778.1 ± 247.7 (n=17)

0.018

0.87

 >135

1058.7 ± 361.1 (n=13)

1041.8 ± 320.0 (n=13)

0.901

0.05

Platelet counts baseline (10^9/L)

    

 ≤200

949.1 ± 368.4 (n=14)

933.0 ± 348.4 (n=16)

0.903

0.05

 >200

1096.4 ± 221.9 (n=15)

845.9 ± 255.0 (n=14)

0.009

1.05

Thrombin time baseline (sec)

    

 ≤17

1013.3 ± 234.8 (n=12)

996.0 ± 360.3 (n=13)

0.889

0.06

 >17

1033.7 ± 353.6 (n=17)

813.2 ± 239.6 (n=17)

0.041

0.73

APTT baseline (sec)

    

 ≤25

855.8 ± 274.2 9 (n=10)

849.8 ± 194.2 (n=8)

0.961

0.02

 >25

1114.7 ± 288.1 (n=19)

938.1 ± 368.8 (n=16)

0.121

0.54

PT baseline (sec)

    

 ≤10.5

986.6 ± 272.7 (n=12)

836.7 ± 238.5 (n=18)

0.122

0.59

 >10.5

1052.6 ± 331.8 (n=17)

975.9 ± 383.3 (n=12)

0.57

0.22

Fibrinogen baseline(g/L)

    

 ≤3

1037.8 ± 344.0 (n=17)

813.2 ± 281.4 (n=19)

0.039

0.72

 >3

1007.6 ± 254.1 (n=12)

1029.0 ± 312.0 (n=11)

0.858

-0.01

  1. The values are given as mean ± standard deviation;
  2. BMI, body mass index; APTT, activated partial thromboplastin time; PT, prothrombin time