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Fig. 4 | Journal of Orthopaedic Surgery and Research

Fig. 4

From: Natural traditional Chinese medicine products: emerging therapeutic targets for the treatment of osteoporosis

Fig. 4

Regulatory mechanism of the PPARγ/Wnt axis in osteoporosis. (Maintaining a delicate balance between adipocyte and osteoblast differentiation necessitates intricate communication among extracellular stimuli and a well-coordinated network of receptors and transcription factors within the nucleus. This network involves key pathways such as RANKL/RANK, Wnt/β-catenin, and PPARγ. Disruption in lipid metabolism can result in elevated levels of oxidized lipids, which, in turn, trigger adipocyte differentiation and hinder osteoblast differentiation through the activation of PPARγ.)

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X