Table 1 Characteristics of studies included in the meta-analysis
Author | Year | Country | duration of model induction | Animal species | gender of animals | animal body weight | Assessment index | Sample size | Intervention | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
E | C | E | C | ||||||||
Chen et al. | 2021 | China | 4w and 8w | Rats | Male | 260 ± 10 g | OARSI | 6 | 6 | 100 ml of 40% [w/v] dECM-CS compound | 100 mlof chitosan |
Choi et al. | 2023 | South Korea | 8w and 12w | Rats | Male | 240–290 g | ICRS | 8 | 8 | isolated dECMs | DPBS |
Zhang et al. | 2024 | China | 6w and 12w | Rabbits | NA | 3.0–3.5 kg | ICRS | 10 | 10 | DMS-CBD + N-SDF1a | N-SDF1a |
Wu et al. | 2025 | China | 6w | Rats | Male | 280–300 g | OARSI | 10 | 10 | 50µL of dECMs | 50µL of saline solution |
Zhang et al. | 2019 | China | 6w and 12w | Rabbits | Female | NA | ICRS | 8 | 8 | ECM | PBS |
Zhang et al. | 2018 | China | 24w and 36w | Goats | Male | 30 ± 5 kg | ICRS | 8 | 8 | Celle-scaffold | Microfracture(nontreated) |
Park et al. | 2016 | South Korea | 2w and 4w | Rabbits | NA | NA | ICRS | 4 | 4 | CECM membranes + PTCD | PTCD |
Meng et al. | 2024 | China | 4w and 8w | Rats | NA | 220–260 g | ICRS | 4 | 4 | dECM | gelatin and PBS |
Gelse et al. | 2017 | Germany | 6w and 26w | Sheep | Female | 70–80 kg | OARSI | 4 | 4 | lateral meniscectomy (LMX) and lateral meniscal allografts (LMA) | nontreated |
Zhu et al. | 2020 | China | 4w and 8w | Rats | NA | 220–260 g | ICRS | 4 | 4 | GelMA/dECM composite hydrogel | PBS |