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Fig. 1 | Journal of Orthopaedic Surgery and Research

Fig. 1

From: Exploring the mechanism by which UCHL3 alleviates diabetic foot ulcers: FOXM1/NLRP3 inflammasome-mediated angiogenesis and endothelial cell pyroptosis

Fig. 1

UCHL3 is lowly expressed in DFU. (A) Volcanic map of differentially expressed genes in GSE134431. (B) The intersection Venn diagram of DEGs with vascular formation related factors downloaded from GeneCard database and DUBs collected from UbiNet 2.0 database. (C) Detection of changes in blood glucose levels in rats before and after modeling. (D) Assessment of alterations in wound healing rate in rats before and after modeling. (E) HE staining was used to compare histological and morphological characteristics of the wound before and after modeling. (F) Immunohistochemical analysis of changes in CD31 expression in wound tissue before and after modeling. (G) Immunohistochemical analysis of changes in eNOS expression in wound tissue before and after modeling. (H) Immunohistochemical analysis of changes in UCHL3 expression in wound tissue before and after modeling. (I) WB detection of changes in angiogenesis-related proteins (VEGF and TSP-1) in rat wound tissues before and after modeling. n = 6. The magnification of images D, E, F and G is 100 times (scale = 400 μm) and 200 times (scale = 200 μm) respectively. **** P < 0.0001. The detection between the two groups was analyzed using t-test. Two factor analysis of variance (ANOVA) will be used for three or more sets of data, and Tukey’s will be used for post hoc testing

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X