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Fig. 5 | Journal of Orthopaedic Surgery and Research

Fig. 5

From: Exploring the mechanism by which UCHL3 alleviates diabetic foot ulcers: FOXM1/NLRP3 inflammasome-mediated angiogenesis and endothelial cell pyroptosis

Fig. 5

Knockdown of FOXM1 leads to pyroptosis of endothelial cells and inhibits angiogenesis. (A) WB detection of FOXM1, NLRP3, and N-GSDMD expression in HUVECs. (B) CCK-8 assay measuring proliferation activity of HUVECs. (C) Scratch wound healing assay detecting migration ability of HUVECs. (D) Tube formation assay evaluating angiogenesis capacity of HUVECs. n = 3. The magnification of images D and E is 100 times (scale = 400 μm). *** P < 0.001, **** P < 0.0001. Three or more sets of data will be analyzed using one-way or two-way ANOVA, and Tukey’s will be used for post hoc testing

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X