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Correction: Inhibition of cc chemokine receptor 10 ameliorates osteoarthritis via inhibition of the phosphoinositide-3-kinase/Akt/mammalian target of rapamycin pathway

Journal of Orthopaedic Surgery and Research volume 20, Article number: 462 (2025) Cite this article

The Original Article was published on 01 March 2024

Correction to: Journal of Orthopaedic Surgery and Research (2024) 19:158 https://doiorg.publicaciones.saludcastillayleon.es/10.1186/s13018-024-04642-x

In this article Figs. 3 and 6 appeared incorrectly and have now been corrected in the original publication. For completeness and transparency, the old incorrect versions are displayed below.

Incorrect Fig. 3:

Fig. 3
figure a

Effects of CCR10-siRNA on IL-1β-induced cell viability, apoptosis and inflammatory cytokines secretion. The CHON-001 cells were divided into four groups: control, IL-1β, IL-1β + control-siRNA, or IL-1β + CCR10-siRNA group. (A) Cell viability was assessed using MTT assay. (B) Analysis of LDH release. (C) Apoptosis was assessed by flow cytometry. (D) Quantification of apoptotic CHON-001 cells. (E) Western blot analysis of cleaved-caspase-3 expression. (F) Relatively cleaved-caspase-3 protein expression were quantified. The secretion of TNF-α (G), IL-6 (H) and IL-8 (I) were evaluated by ELISA. (J) Western blot analysis of MMP-3, MMP-13, Collagen II, and Aggrecan. (K) MMP-3/β-actin ratio. (L) MMP-13/β-actin ratio. (M) Collagen II /β-actin ratio. (N) Aggrecan/β-actin ratio. **P < 0.01

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Correct Fig. 3:

Fig. 3
figure 3

Effects of CCR10-siRNA on IL-1β-induced cell viability, apoptosis and inflammatory cytokines secretion. The CHON-001 cells were divided into four groups: control, IL-1β, IL-1β + control-siRNA, or IL-1β + CCR10-siRNA group. (A) Cell viability was assessed using MTT assay. (B) Analysis of LDH release. (C) Apoptosis was assessed by flow cytometry. (D) Quantification of apoptotic CHON-001 cells. (E) Western blot analysis of cleaved-caspase-3 expression. (F) Relatively cleaved-caspase-3 protein expression were quantified. The secretion of TNF-α (G), IL-6 (H) and IL-8 (I) were evaluated by ELISA. (J) Western blot analysis of MMP-3, MMP-13, Collagen II, and Aggrecan. (K) MMP-3/β-actin ratio. (L) MMP-13/β-actin ratio. (M) Collagen II /β-actin ratio. (N) Aggrecan/β-actin ratio. **P < 0.01

Full size image

Incorrect Fig. 6:

Fig. 6
figure b

Effects of CCR10-siRNA or 740Y-P on IL-1β-induced cell viability, apoptosis, and inflammatory cytokines secretion. The CHON-001 cells were divided into three groups: IL-1β + control-siRNA, IL-1β + CCR10-siRNA, and IL-1β + CCR10-siRNA + 740Y-P groups. (A) MTT assay for cell viability. (B) Determination of LDH level. (C) Apoptotic cells were evaluated using flow cytometry. (D) Quantification of the apoptotic cells. (E) Determination of cleaved-caspase-3 expression. (F) Quantization of cleaved-caspase-3 expression. The levels of TNF-α (G), IL-6 (H), and IL-8 (I) were analyzed using ELISA. (J) Western blot analysis of MMP-3, MMP-13, Collagen II, and Aggrecan. (K) MMP-3/β-actin ratio. (L) MMP-13/β-actin ratio. (M) Collagen II /β-actin ratio. (N) Aggrecan/β-actin ratio. **P < 0.01

Full size image

Correct Fig. 6:

Fig. 6
figure 6

Effects of CCR10-siRNA or 740Y-P on IL-1β-induced cell viability, apoptosis, and inflammatory cytokines secretion. The CHON-001 cells were divided into three groups: IL-1β + control-siRNA, IL-1β + CCR10-siRNA, and IL-1β + CCR10-siRNA + 740Y-P groups. (A) MTT assay for cell viability. (B) Determination of LDH level. (C) Apoptotic cells were evaluated using flow cytometry. (D) Quantification of the apoptotic cells. (E) Determination of cleaved-caspase-3 expression. (F) Quantization of cleaved-caspase-3 expression. The levels of TNF-α (G), IL-6 (H), and IL-8 (I) were analyzed using ELISA. (J) Western blot analysis of MMP-3, MMP-13, Collagen II, and Aggrecan. (K) MMP-3/β-actin ratio. (L) MMP-13/β-actin ratio. (M) Collagen II /β-actin ratio. (N) Aggrecan/β-actin ratio. **P < 0.01

Full size image

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Authors and Affiliations

  1. General Practice, Wuhan Puren Hospital, Wuhan, 430080, China

    Yan Luo & Yi Li

  2. Nutrition Department, Wuhan Puren Hospital, Wuhan, 430080, China

    Feng Zhou

  3. Cardiology Department, Wuhan Puren Hospital, Wuhan, 430080, China

    Xiaojing Wang

  4. Rheumatology Immunology Department, Wuhan Puren Hospital, Wuhan, 430080, China

    Runwei Yang

  5. Orthopedics Department, Wuhan Huangpi People’s Hospital, Wuhan, 430300, China

    Xiaochun Wu

  6. Orthopedics Department, Wuhan No. 9 Hospital, No. 20 Jilin Street, Wuhan, 430080, China

    Bin Ye

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  1. Yan Luo
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  2. Feng Zhou
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Correspondence to Bin Ye.

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Luo, Y., Zhou, F., Wang, X. et al. Correction: Inhibition of cc chemokine receptor 10 ameliorates osteoarthritis via inhibition of the phosphoinositide-3-kinase/Akt/mammalian target of rapamycin pathway. J Orthop Surg Res 20, 462 (2025). https://doiorg.publicaciones.saludcastillayleon.es/10.1186/s13018-025-05807-y

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  • DOI: https://doiorg.publicaciones.saludcastillayleon.es/10.1186/s13018-025-05807-y

Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X