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The secretion of mitochondrial-derived vesicles (MDVs) has been found to increase during osteogenic differentiation, but their role in intercellular communication and osteogenic promotion remains unclear. In t...
Patients with end-stage hip disease are classified into distinct spinal-hip types according to sagittal spinal-hip parameters. Each type employs specific compensatory strategies to maintain balance, but the as...
Nerve root compression in the lumbar intervertebral foramen (LIVF) is a consistent feature of radicular syndrome. There is debate about movements and positions that may reduce compression for possible use in c...
To evaluate the functional outcomes of arthroscopic onlay dynamic anterior stabilization (DAS) using the long head of the biceps (LHB) tendon for treatment of anterior glenohumeral instability (AGI) with limit...
Knee osteoarthritis (KOA) is a prevalent chronic joint disease. Due to the risks of opioid use and limited pharmacological effectiveness, mind–body exercise (MBE) therapy and other non-pharmacological interven...
Osteoarthritis (OA) is the leading cause of degenerative joint disease, with total joint replacement as the only definitive cure. However, no disease-modifying therapy is currently available. Inflammation and ...
Systemic lupus erythematosus (SLE) can lead to avascular necrosis (AVN) of the femoral head, often requiring total hip arthroplasty (THA). However, outcomes and complications of THA in SLE patients remain uncl...
Chronic lateral ankle instability (CLAI) is a common condition often associated with damage to the anterior talofibular ligament (ATFL). In cases where CLAI is accompanied by subtalar instability (STI) due to ...
Tendon injury is a common and frequent disease in the field of sports medicine, and tendon repair after injury is a common clinical difficulty. Repair strategy based on tendon stem cells (TDSCs) therapy is con...
Incidental durotomy (ID) during spinal surgery is common during spinal surgery. This study aimed to determine whether intraoperative ID affects the perioperative and long-term clinical outcomes in patients wit...
Total en bloc spondylectomy (TES) was considered aggressive spinal surgery aim to achieved marginal and wide surgical margin in spinal tumor treatment. However, there was limited comparison information between...
Metacarpal neck fractures are common and there are numerous surgical methods available, but each has certain disadvantages and limitations. We modified the conventional Ilizarov external mini-fixator and this ...
The original article was published in Journal of Orthopaedic Surgery and Research 2023 18:203
Returning to driving is a significant milestone for patients recovering from spine surgery, representing restored independence, mobility, and mental well-being. However, this decision involves numerous challen...
Osteoarthritis (OA), a degenerative joint disease characterized by cartilage degradation and inflammation, lacks effective disease-modifying therapies. Quercetin, a bioactive flavonoid derived from Traditional...
Scoliosis considerably affects adolescents’ physical well-being and quality of life. Current research offers scant data concerning the correlation between abnormal posture, screen time, physical activity, and ...
The aim of this study is to evaluate the effects of midshaft femoral derotation surgery on the alignment of the lower limbs in the coronal and sagittal planes, as well as its impact on pelvic parameters in pat...
The trabecular architecture of proximal femur plays a crucial role in hip stability and load distribution and is often ignored in hip fracture fixation due to limited anatomical knowledge. This study analyses ...
The property of in vivo osteoinductivity (OI) has been reported in synthetic calcium phosphates bone grafts, including silicate-containing calcium phosphates in different animal intramuscular defect models. Ho...
Oxidised regenerative cellulose (ORC) is an absorbable haemostatic agent that acts independently on the blood coagulation mechanisms. Although ORC products have been used as adjuncts in various surgical proced...
This study aimed to investigate the regulatory effect of linc00963 on postmenopausal osteoporosis and the potential molecular mechanisms.
Joint space narrowing (JSN) and osteophytes are rarely studied separately regarding their risk factors and impacts on knee symptoms and function, particularly in the Chinese population.
Decreased size and mass of paraspinal muscles are associated with lower vertebral bone mineral density, more postoperative complications, increased mortality, and spinal sagittal imbalance. However, it is diff...
Rotator cuff tears affect approximately 20% of the population and are usually repaired arthroscopically. The clinical outcomes of these repairs are influenced by multiple factors, including patient characteris...
This study evaluated the clinical and radiological outcomes of lateral tibial plateau fractures involving the central and postero-lateral regions, comparing an extended lateral approach with lateral epicondyle...
The COVID-19 pandemic has claimed many lives and continues to impact individuals through post-COVID-19 conditions. Osteonecrosis of the femoral head (ONFH) is increasingly recognized as a major post-COVID-19 c...
Ingrown toenails significantly impact quality of life. This study compares the clinical outcomes of the modified Winograd method versus partial resection with matrix electrocoagulation. We hypothesize that ele...
The cervical spine’s mobility affects the compression level of the cervical cord which varies with dynamic positioning. High signal on MRI T2-weight imaging (MRI-T2WI) of the cervical cord indicates a poorer p...
Despite the well-known benefits of calcitriol and bisphosphonates in managing osteoporosis, limited research has explored the combined therapeutic effects of these agents on bone metabolism, immune function, a...
The original article was published in Journal of Orthopaedic Surgery and Research 2022 17:246
To compare the treatment outcomes of unilateral unichannel and bichannel endoscopic Unilateral Laminotomy for Bilateral Decompression (ULBD) surgery in patients with lumbar spinal stenosis and analyze factors ...
This study aims to investigate whether Hounsfield unit (HU) value is correlated with intervertebral disc (IVD) degeneration (IVDD) by comparing premenopausal with menopausal women patients.
The original article was published in Journal of Orthopaedic Surgery and Research 2023 18:848
The efficacy and safety of platelet-rich plasma (PRP) combined with core decompression (CD)-enhanced bone grafting for the treatment of osteonecrosis of the femoral head remains controversial. This study aimed...
No studies have assessed the correlation between preoperative medial meniscus extrusion (MME) and subchondral bone marrow edema (BME) or which factor influences the outcomes after medial opening wedge high tib...
To explore the clinical efficacy and advantages of Arthroscopic-assisted Uni-portal Spinal Surgery (AUSS)-Transforaminal Lumbar Interbody Fusion (TLIF) in the treatment of degenerative lumbar spinal stenosis (...
The Correction to this article has been published in Journal of Orthopaedic Surgery and Research 2025 20:401
Obstructive sleep apnea (OSA) is a prevalent sleep disorder associated with intermittent hypoxia, oxidative stress, and systemic inflammation, posing risks for adverse postoperative outcomes, including surgica...
Medial meniscus (MM) injuries are common and often contribute to knee osteoarthritis (KOA). While studies focus on joint degeneration, the role of extrinsic factors such as postural control remains underexplor...
Endothelium-derived exosomes has been reported to enhanced osteogenesis. However, the role of endothelial exosomes on osteoclastgenesis is still unknown.
Suture and knotless anchor onlay tenodesis are two common treatments for biceps lesions; however, there is a paucity of biomechanical studies evaluating the efficacy and structural integrity of these techniques.
This comprehensive meta-analysis aimed to elucidate the effects of anti-osteoporosis (OP) drugs in patients who experienced rotator cuff tears and underwent arthroscopic repair.
To analyze changes in the expression of osteoporosis (OP)-related genes across different bone types based on transcriptome sequencing, and to identify the key molecules and mechanisms involved in the progressi...
Schatzker IV–VI tibial plateau fractures usually happen in the weight-bearing part of the knee joint. They are hard to fix with traditional methods because they damage soft tissues and make it hard to get back...
To compare the efficacy of personalized osteotomies with that of standard osteotomies in treating medial unicompartmental knee osteoarthritis.
This study aimed to compare the clinical efficacy of Jingshang Gao in the treatment of lateral ankle sprains by observing the healing process with musculoskeletal ultrasound.
Severe rigid spinal deformities present significant challenges in correction surgery due to complexity and associated comorbidities. To mitigate the surgical risks, preoperative halo-pelvic traction (HPT) have...
Locked plating of femur fractures is associated with secondary peri-implant fractures which may be a result of stress concentrations at the proximal plate end region. The aim of this study was to investigate w...
The lack of standardized Platelet-Rich Plasma (PRP) protocols for Knee Osteoarthritis (KOA), combined with significant patient variability, leads to inconsistent PRP effectiveness across studies. This study ai...
Total knee arthroplasty (TKA) is a widely performed surgical intervention for symptomatic knee osteoarthritis (OA). However, the influence of coronal plane alignment on clinical outcomes remains unclear. This ...
In this letter to the editor, we highlight several concerns that may affect the validity of the study results by Luo et al. entitled “Effect of Buttres plate in Herscovici type D vertical medial malleolar frac...
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Journal of Orthopaedic Surgery and Research