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In arthroscopic rotator cuff repair, satisfactory postoperative outcomes can be achieved by simplifying the surgical procedure and ensuring proper integration of the deep rotator cuff tissue with the footprint...
MicroRNAs regulate the OPG/RANKL/RANK signaling pathway, which is crucial for postmenopausal osteoporosis (PMO) development. Explore the role of miR-217 in PMO by regulating the OPG/RANKL/RANK signaling pathway.
Kruppel-like factor 9 (KLF9) is involved in the development of osteoarthritis (OA), which is a chronic joint disorder. However, the pathogenesis of OA remains unclear. This study aimed to investigate the relat...
Medial open-wedge high tibial osteotomy (MOWHTO) is effective for treating medial-compartment knee osteoarthritis but carries a risk of lateral hinge fractures (LHF), compromising stability and outcomes. Hinge...
The incidence of anterior cruciate ligament (ACL) reconstructions among adolescents, particularly those involved in high-risk sports, has increased. Despite surgical advancements, outcomes remain worse than in...
The original article was published in Journal of Orthopaedic Surgery and Research 2024 19:144
Platelet-rich plasma (PRP) is commonly used alone or in combination with hyaluronic acid (HA) in the treatment of knee osteoarthritis. A recently published meta-analysis and systematic review compared outcomes...
The BioBone consortium aims to validate circulating CD8 + TEMRA cells as a prognostic biomarker for predicting impaired fracture healing outcomes in a prospective, blinded, multicenter clinical study. The prim...
Longitudinal changes in functional levels can provide valuable information regarding patient-reported outcome measures (PROMs). However, the longitudinal outcomes of lumbar fusion surgery in patients with meta...
Magnetically controlled intramedullary lengthening nails offer a fully internal approach to limb lengthening, avoiding complications associated with external fixators such as pin site infections and soft tissu...
To compare operative efficiency and safety profiles between a novel C-Flex Traction™ and conventional traction systems during supine intramedullary nailing of geriatric pertrochanteric fractures.
The Both Column Fixation Corridor (BCFC) and Both Column Screws (BCS) represent innovative concepts in orthopedic surgery, yet they have not been extensively studied in the literature. This study aims to valid...
While venous thromboembolism (VTE) prophylaxis is crucial following major orthopaedic surgeries including total knee arthroplasty (TKA), the impact of different prophylactic agents on postoperative hemoglobin ...
Cage subsidence (CS) is a significant complication following oblique lateral interbody fusion combined with bilateral pedicle screw fixation (OLIF-BPSF) in patients with spinal degenerative diseases (SDDs). Id...
The original article was published in Journal of Orthopaedic Surgery and Research 2025 20:495
Intervertebral disc degeneration (IVDD) is a leading cause of lower back pain, imposing significant healthcare burdens globally. However, the molecular mechanisms underlying IVDD remain elusive, limiting effec...
To compare the clinical outcomes of arthroscopic internal drainage (AID) and arthroscopic internal drainage combined cyst wall resection(AID + CWR) in treatment of the popliteal cysts.
Retrograde tibial nailing (RTN) is a relatively new, minimally invasive technique for managing distal tibial fractures. Studies have demonstrated that RTN provides superior biomechanical stability compared to ...
Spinal anesthesia (SA) is widely used for total knee arthroplasty (TKA) due to its advantages in postoperative pain control and reduced opioid use. However, prolonged motor and sensory blockade remains a conce...
Exosomes are nanosized membrane vesicles secreted by cells that have garnered considerable attention in the biomedical field in recent years. Osteoarthritis (OA) is a common disabling joint disease with limite...
A clear surgical field of view is one of the key factors for a smooth operation. Whether a new modified oblique retractor can improve the field of view during oblique lumbar interbody fusion (OLIF) surgery and...
Thoracolumbar fractures involving severe collapse of the anterior and middle columns are difficult to reduce via posterior surgery. Therefore, we evaluated the effectiveness of balloon-assisted endplate reduct...
The optimal surgical approach for tibial avulsion fractures of the posterior cruciate ligament (PCL) remains controversial. This study aimed to compare the clinical outcomes of four techniques: arthroscopic su...
Minimal data exists on whether adolescents with both autism spectrum disorder (ASD) and scoliosis exhibit distinct curve types or require varying surgical management compared to neurotypical adolescents. Our s...
The optimal surgical techniques for cervical ossification of the posterior longitudinal ligament (OPLL) remain controversial due to insufficient high-level evidence. We investigated the following surgical appr...
In complex primary cases– marked by significant ligamentous instability, extensive bone loss, or severe deformities– standard total knee arthroplasty (TKA) may be insufficient. Rotating-hinge (RH) TKA offers a...
To evaluate the effectiveness and safety of the lateral position posterior surgery ahead of the anterior surgery (LP-A) in a single stage for releasing the cervical spinal cord from short-term severe anterior ...
We commend Seong et al. for exploring associations between COVID-19 and osteonecrosis of the femoral head (ONFH). However, their retrospective single-center study (N = 84) has critical limitations. The exclusion ...
The original article was published in Journal of Orthopaedic Surgery and Research 2025 20:362
The Matters Arising to this article has been published in Journal of Orthopaedic Surgery and Research 2025 20:572
The original article was published in Journal of Orthopaedic Surgery and Research 2025 20:573
Peripheral nerves within the bone actively participate in bone remodelling by secreting various bioactive molecules, and dysfunction or changes in their abundance greatly contribute to the onset of osteoporosi...
Knee replacement (KR) is the most common osteoarthritis (OA) related surgery. Studies suggest that there are major international and national disparities in pre-operative information, support and access to reh...
The effect of shoulder pathologies on glenoid bone mineral density (BMD) remains unclear and can be critical in surgical treatments. It is thus useful to predict this effect and understand how it is influenced...
Osteoporotic vertebral compression fractures (OVCFs) are common in osteoporosis patients. Vertebral augmentation procedures like percutaneous vertebroplasty (PVP) and percutaneous kyphoplasty (PKP) are widely ...
Artificial intelligence (AI), particularly large language models (LLMs) such as ChatGPT, is increasingly studied in healthcare. This study evaluated the accuracy and reliability of the ChatGPT in guiding famil...
Peripheral nerve injury (PNI) is currently an intractable disease for clinical therapeutics. Schwann cells (SCs) play pivotal roles in peripheral nerve regeneration. Naringin, a natural flavonoid, has potent b...
Proximal humeral fractures are common injuries in the elderly population, with their incidence expected to rise due to increased life expectancy. A small subset of these fractures may be associated with disloc...
Rheumatoid arthritis (RA) is a systemic autoimmune disease that primarily affects the synovial membrane, leading to progressive joint destruction. Among RA-related deformities, forefoot deformities are particu...
Statistical Shape Models are machine learning tools in computational orthopedics that enable the study of anatomical variability and the creation of synthetic models for pathogenetic analysis and surgical plan...
The treatment of massive anterior L-shaped rotator cuff tears (RCTs) remains challenging. This study focused on restoration of humeral head coverage by superiorly repositioning the rotator interval tissue. The...
Olecranon fractures (OFs) account for approximately 20% of proximal forearm fractures. Displaced or unstable OFs are typically treated surgically with tension-band wiring (TBW) or plate fixation (PF). While co...
There are no clear criteria for decision-making after proximal humeral fractures, and the choice of surgical strategy and, in particular, timing is controversial. Vascular disruption can lead to delayed avascu...
Femoral neck system (FNS) and cannulated screws combined with medial plate (CS with medial plate) both are commonly used internal fixation for femoral neck fractures in recent years. There is a debate that whi...
Moldable calcium phosphate (MCaP) biomaterials have been studied as osteoconductive scaffolds for bone regeneration. However, their potential as carriers for recombinant human bone morphogenetic protein-2 (rhB...
Previous research has demonstrated the therapeutic potential of aerobic exercise in alleviating symptoms of knee osteoarthritis (KOA). Nevertheless, comparative evidence regarding the relative effectiveness of...
This study integrates Mendelian randomization (MR) analysis with animal experiments to systematically evaluate the therapeutic efficacy of varying concentrations of hypertonic dextrose on tendon injury and elu...
Humeral capitellum osteochondritis dissecans (OCD) is a common condition among overhead throwing athletes and is typically treated surgically. While stable lesions can be treated nonoperatively, untreated unst...
In medial compartment osteoarthritis (OA) of the knee in young patients who fail conservative treatment, clinical equipoise exists between three surgical strategies: (1) total knee arthroplasty (TKA), (2) unic...
Posterior hemivertebra resection (HVR) with fusion is a widely accepted technique for congenital early-onset scoliosis (CEOS). However, the optimal fusion length remains debated. This study compares the long-t...
Calcaneal fractures usually arise from high-energy trauma and predominantly impact young individuals. In older adults (aged ≥ 50 years), declining bone density and muscle strength increase fracture risk from l...
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Journal of Orthopaedic Surgery and Research